https://example.com/tags/capacitance-based-sensing/Capacitance-Based SensingHugoBlox Kit (https://hugoblox.com)en-usTue, 04 Mar 2025 00:00:00 +0000https://example.com/media/icon_hu_702a800cd775dbac.pnghttps://example.com/tags/capacitance-based-sensing/https://example.com/projects/biochip/Tue, 04 Mar 2025 00:00:00 +0000https://example.com/projects/biochip/<h2 id="project-description">Project Description</h2> <p>This research project focuses on developing <strong>microfluidic-based biochips for rapid biomarker detection</strong> in point-of-care (POC) applications. The platform integrates blood-plasma separation, controlled microfluidic transport, and capacitance-based biosensing into a compact system designed to reduce sample-processing requirements and detection time.</p> <p>A key component of the project is the design and fabrication of <strong>microchannels for the passive separation of plasma from whole blood</strong>. The microfluidic architecture is engineered to regulate sample flow, minimize cellular interference, and deliver plasma efficiently to the sensing region without relying on bulky external separation equipment.</p> <p>The sensing platform employs <strong>functionalized interdigitated electrodes</strong> to detect target biomarkers through changes in electrical capacitance. The electrode geometry, surface functionalization, and microchannel configuration are optimized to enhance <strong>sensitivity, specificity</strong>, signal stability, and reproducibility while requiring only a small sample volume (finger pirck blood).</p> <p>This research aims to establish a rapid, compact, and minimally invasive diagnostic platform that can support decentralized biomarker testing. By combining microfluidic sample preparation with capacitance-based sensing, the project contributes to the development of accessible POC technologies for clinical screening, disease monitoring, and early diagnosis.</p> <p>We are currently focused on the early detection of <strong>Ovarian Cancer (CA 125, HE4) and Alzheimer&rsquo;s disease (Aβ40, Aβ42, p-tau)</strong>.</p>